Product 9199

In Stock

Catalog ID 9199 / 5 mg

DBF Cytochrome P450 Substrate

AKA: Dibenzylfluorescein

Formula	Weight	CAS#
C₃₄H₂₄O₅	512.55	97744-44-0

1-4 - ¤ 238/Unit 5-24 - ¤ 225/Unit

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DBF is dealkylated by cytochromes P450 (especially CYP2C8, CYP2C9, CYP2C19, and CYP3A) to form a fluorescein ester. Dibenzylfluorescein was reported to be suitable for in vitro assessment of the initial screening of CYP3A4- mediated drug interactions. The fluorescent fluorescein product can be quantitated after the addition of base, which hydrolyzes the ester and increases the pH for optimal fluorescein fluorescence detection, which hydrolyzes the ester and increases the pH for optimal fluorescein fluorescence detection.

Product Size	5 mg
Form	Orange Solid
Absorption (estimated)	Wavelength (λmax) 458 ± 3 nm (Methanol)
Storage conditions	Freeze: Store at -5 to -30°C (F) Protect from moisture (D) Protect from light (L)
MDL#	MFCD13184323

* Dibenzylfluorescein
* Benzyl 2-(6-(benzyloxy)-3-oxo-3H-xanthen-9-yl)benzoate
* NSC 645658

Enzyme Detection, Substrates and Activity Assays :	Cytochrome P450 Substrates
Fluorescent Probes and Related Products:	Fluorescein, Naphthofluorescein and seminaphthofluorescein