Product 6171

In Stock

Catalog ID 6171 / 25 mg

5,5'-Dinitro BAPTA, AM Cell permeant

AKA: 1,2-Bis(2-amino-5-nitrophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl) ester

Formula	Weight	CAS#
C₃₄H₃₈N₄O₂₂	854.68	172646-47-8

1-4 - ¤ 292/Unit 5-24 - ¤ 276/Unit

For 25+ Units, Contact us.

5,5'-Dinitro BAPTA, AM is a cell membrane-permeant derivative of the calcium-selective chelator, BAPTA. The 5,5’ dinitro groups greatly reduce the Ca²⁺ binding affinity of this BAPTA analog. 5,5'-Dinitro BAPTA, AM is commonly used as a low-affinity, intracellular Ca²⁺ buffer for investigations of the role of cytosolic Ca²⁺. Live cells are passively loaded with 5,5'-Dinitro BAPTA, AM by incubation with cell-permeant AM esters. Once internalized, cytosolic esterases cleave the AM esters to liberate the active tetra-carboxylate ligand. 5,5'-Dinitro BAPTA, AM may also be used as a synthetic building block for the synthesis of novel, cell-permeant, fluorescent ion indicators. .

Product Size	25 mg
Form	Y-solid
Absorption (estimated)	Wavelength (λmax) 376 ± 3 nm (Methanol)
Storage conditions	Freeze: Store at -5 to -30°C (F) Protect from moisture (D) Protect from light (L)
MDL#

* 1,2-Bis(2-amino-5-nitrophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl) ester
* Glycine, N,N'-[1,2-ethanediylbis[oxy(4-nitro-2,1-phenylene)]]bis-[N-[2-[)acetoxy)methyl]-2-oxoethyl]-, bis[(acetoxy)methyl] ester

X do not use 23:	BAPTA
Building Blocks/Intermediates
Cellular Sensors, Ion and pH Indicators (Fluorescent/Non-Fluorescent):	Non-Fluorescent Calcium and pH Indicators and Related Products