Product 6171
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Catalog ID 6171 / 25 mg
5,5'-Dinitro BAPTA, AM *Cell permeant*
AKA: 1,2-Bis(2-amino-5-nitrophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl) ester
Formula | Weight | CAS# |
---|---|---|
C34H38N4O22 | 854.68 | 172646-47-8 |
For 25+ Units, Contact us.
5,5'-Dinitro BAPTA, AM is a cell membrane-permeant derivative of the calcium-selective chelator, BAPTA. The 5,5’ dinitro groups greatly reduce the Ca2+ binding affinity of this BAPTA analog. 5,5'-Dinitro BAPTA, AM is commonly used as a low-affinity, intracellular Ca2+ buffer for investigations of the role of cytosolic Ca2+. Live cells are passively loaded with 5,5'-Dinitro BAPTA, AM by incubation with cell-permeant AM esters. Once internalized, cytosolic esterases cleave the AM esters to liberate the active tetra-carboxylate ligand. 5,5'-Dinitro BAPTA, AM may also be used as a synthetic building block for the synthesis of novel, cell-permeant, fluorescent ion indicators. .
Product Size | 25 mg |
---|---|
Form | Y-solid |
Absorption (estimated) | Wavelength (λmax) 376 ± 3 nm (Methanol) |
Storage conditions | Freeze: Store at -5 to -30°C (F) Protect from moisture (D) Protect from light (L) |
MDL# |
* 1,2-Bis(2-amino-5-nitrophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl) ester
* Glycine, N,N'-[1,2-ethanediylbis[oxy(4-nitro-2,1-phenylene)]]bis-[N-[2-[)acetoxy)methyl]-2-oxoethyl]-, bis[(acetoxy)methyl] ester
* Glycine, N,N'-[1,2-ethanediylbis[oxy(4-nitro-2,1-phenylene)]]bis-[N-[2-[)acetoxy)methyl]-2-oxoethyl]-, bis[(acetoxy)methyl] ester
X do not use 23: | BAPTA |
---|---|
Building Blocks/Intermediates | |
Cellular Sensors, Ion and pH Indicators (Fluorescent/Non-Fluorescent): | Non-Fluorescent Calcium and pH Indicators and Related Products |
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