mBCl [Monochlorobimane]

Catalog ID: 6063 UNIT SIZE: 25 mg

mBCl [Monochlorobimane]

C10H11ClN2O2
226.66
76421-73-3
MFCD00077379
1-4 ($159.00/Unit) 5-24 ($152.00/Unit) 25-49 ($139.00/Unit)

Description

Monochlorobimane is a low molecular weight, non-ionic, fluorescent probe for labeling thiols. This cell-permeant probe is essentially non-fluorescent until it reacts with a thiol group. The chloromethyl group is relatively selective for reaction with thiols at physiological pH but may also react with carboxylates at pH above 7. Monochlorobimane is useful to quantify and detect the distribution of glutathione in living cells and tissue homogenates. This low molecular weight label can also be used to derivatize thiol-containing proteins prior to electrophoresis without disturbing the protein’s mobility in the separation. The conjugates of monochlorobimane are optimally excited near 394 nm and have a variable emission near 490 nm. Please see related products below.

Documents

Safety Data Sheet
SDS: SDS 6063.pdf
Certificate of Analysis
Lot Number: 51102
Product Manuals
No Documents Available

Images

No Images Available

Product Information

Product Size 25 mg
Form Solid
Category Fluorescent Probes and Related Product:
Bimane

Reactive Probes and Related Products:
Thiol-Reactive (Haloacetamide/Halobenzyl and Maleimide)
Absorption (estimated) Wavelength (λmax) 380 ± 3 nm
Fluorescence (estimated)
Wavelength (λmax) 490± 4 nm, in buffer pH 8, after reaction with thiol
Storage conditions Freeze: Store at -5 to -30°C (F)
Protect from moisture (D)
Protect from light (L)
Shipping conditions Room temperature
  • • 1H,7H-Pyrazolo(1,2-α)pyrazole-1,7-dione, 3-(chloromethyl)-2,5,6-trimethyl

    • Chlorobimane

• Culturing at atmospheric oxygen levels impacts lymphocyte function." Atkuri KR, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A 102, 3756-9 (2005)

Low-molecular-mass thiol compounds from a free-living highly pathogenic amoeba, Naegleria fowleri." Ondarza RN, Iturbe A, Hernandez E, Hurtado G. Biotechnol Appl Biochem 37, 195-204 (2003)

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For Research Use Only. Not for any animal or human therapeutic

or diagnostic use

No Animal source

Regulatory Compliance

6063

mBCl [Monochlorobimane]

OSHA Hazard

No Known OSHA Hazards

HMIS Classification

Health: 0

Flammability: 0

Physical Hazard: 0

NFPA Rating

Health: 0

Fire:  0

Reactivity: 0

TSCA Status

Not On TSCA Inventory

Transportation Information

DOT (US)

IMDG

IATA

Not Dangerous Good

Not Dangerous Good

Not Dangerous Good

 

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