Catalog ID: 6278 UNIT SIZE: 5 mg

Rh110-2(Asp) D2R D)2-Rh 110 (trifluoroacetate salt)

Rhodamine 110, bis-(L-aspartic acid amide), trifluoroacetic acid salt

MOL. FORMULA

C32H26F6N4O13

MOL. WEIGHT

788.57

CAS NUMBER

220846-63-9

MDL NUMBER

N/A

Description

Rh110-2(Asp) is a cell-permeant fluorogenic enzyme substrate for the caspase proteases that are associated with apoptosis. Rh110-2(Asp) is a common substrate for the caspases, a family of enzymes that exhibit proteolytic activity targeting aspartic acid (Asp) in the P1 position of substrates. Rh110-2(Asp) is non-fluorescent until enzymatic cleavage of the Asp groups liberates the green-fluorescent Rh110 dye in a two-step hydrolysis pathway. Enzymatic activity is detected by fluorescence with the excitation near 496 nm and fluorescent emission near 520 nm. Please see other related products at the bottom of this page.

Documents

Safety Data Sheet

SDS: SDS 6278.pdf

Certificate of Analysis

Lot Number: 11707-1
Lot Number: ST14452

Product Manuals

No Documents Available

Images

No Images Available

Product Information

Product Size	5 mg
Form	Solid
Absorption (estimated)	Wavelength (λmax) 234 ± 3 nm
Fluorescence (estimated)	Excitation / Emission maxima about 496 ± 3 nm / 520 ± 4 nm nm after enzymatic hydrolysis
Cell Permeability	Cell-permeant
Detection Method	Fluorescent enzymatic product
Storage conditions	Freeze: Store at -5 to -30°C (F) Protect from moisture (D) Protect from light (L)
Shipping conditions	Room temperature

Storage

Storage Condition
Store -5 to -30^oC (F)	Protect from Moisture (D)	Protect from Light (L)

Synonyms

• Butanoic acid, 4,4'-[(3-oxospiro[isobenzofuran-1(3H0,9'-[9H]xanthene]-3'6'-diyl)diimino]bis[3-amino-4-oxo-, (3S,3'S)-, bis(trifluoroacetate)

• D₂R
Rh110-2(Asp) Caspase Substrate

Citations And References

• Mukhopadhyay P, Rajesh M, Bátkai S, Kashiwaya Y, Haskó G, Liaudet L, Szabó C, Pacher P, Am J Physiol Heart Circ Physiol (2009) 296:H1466-H1483

• Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT. J Neurosci 22, 7006-15 (2002)

• Biochem. 38, 13906 (1999)

Regulatory Compliance

For Research Use Only. Not for any animal or human therapeutic or diagnostic use No Animal source
Regulatory Compliance
6278	Rh110-2(Asp) [Rhodamine 110, bis-(L-aspartic acid amide), trifluoroacetic acid salt]
OSHA Hazard			No Known OSHA Hazards
HMIS Classification			Health: 0	Flammability: 0		Physical Hazard: 0
NFPA Rating			Health: 0	Fire: 0			Reactivity: 0
TSCA Status			Not On TSCA Inventory
Transportation Information
DOT (US)		IMDG			IATA
Not dangerous goods		Not dangerous goods			Not dangerous goods