Catalog ID: 6284 UNIT SIZE: 5 mg

BZAR [Rhodamine 110, bis-(CBZ-L-argenine amide), dihydrochloride salt]

MOL. FORMULA

C48H52Cl2N10O9

MOL. WEIGHT

983.89

CAS NUMBER

N/A

MDL NUMBER

N/A

Description

BZAR is a fluorogenic enzyme substrate for serine proteases. BZAR is non-fluorescent and colorless until enzymatic activity results in cleavage of one of the amide bonds and converts the non-fluorescent bis-amide substrate into a highly fluorescent monoamide product. Enzymatic activity is detected by fluorescence with an excitation near 492 nm and emission near 523 nm. BZAR is recognized for providing much greater sensitivity to enzymatic activity than similar coumarin-based fluorogenic-enzymatic assays. BZAR is also a known inhibitor of guanidinobenzoatase activity in tumor cells. Please see other related products at the bottom of this page.

Documents

Safety Data Sheet

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Certificate of Analysis

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Product Manuals

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Product Information

Product Size	5 mg
Form	Solid
Absorption (estimated)	Wavelength (λmax) 232 ± 3 nm
Fluorescence (estimated)	Excitation / Emission maxima about 492 nm / 532 nm after enzymatic cleavage
Detection Method	Fluorescent after enzymatic cleavage
Storage conditions	Freeze: Store at -5 to -30°C (F) Protect from moisture (D) Protect from light (L)
Product Size	Room temperature

Storage

Storage Condition

Protect from Light

(PL)

Protect from Moisture

(PM)

Store at -20^oC

(F)

Synonyms

((((3-Oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl)bis(azanediyl))bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentane-5,1-diyl))bis(azanediyl))bis(aminomethaniminium) chloride

Citations And References

• Biochem J, 215, 253 (1983)

• Biochem J, 209, 299 (1983)

Regulatory Compliance

For Research Use Only. Not for any animal or human therapeutic or diagnostic use No Animal source
Regulatory Compliance
6284	BZAR [Rhodamine 110, bis-(CBZ-L-argenine amide), dihydrochloride salt]
OSHA Hazard			No Known OSHA Hazards
HMIS Classification			Health: 0	Flammability: 0		Physical Hazard: 0
NFPA Rating			Health: 0	Fire: 0			Reactivity: 0
TSCA Status			Not On TSCA Inventory
Transportation Information
DOT (US)		IMDG			IATA
Not dangerous goods		Not dangerous goods			Not dangerous goods