Nitisinone [NTBC, Orfadin]

Catalog ID: 9024 UNIT SIZE: 1 g

Nitisinone [NTBC, Orfadin]

C14H10F3NO5
329.23
104206-65-7
MFCD01752192
1-4 ($120.00/Unit) 5-24 ($115.00/Unit) 25-49 ($110.00/Unit)

Description

Nitisinone, herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. Nitisinone is used in treatment of inherited tyrosinemia type I, where it blocks the degradation of tyrosine into harmful substances

Images

No Images Available

Documents

Safety Data Sheet
SDS: SDS 9024.pdf

Certificate of Analysis
Lot Number: 50966
Lot Number: 51261

Product Manuals
No Documents Available


 

Storage Condition

Protect from Light (PL)

Protect from Moisture (PM)

Store at 4-8oC (Ref)

 

 

Analytical Data & Specification

9024

Nitisinone  [NTBC, Orfadin]

 

Standard

Observed

HPLC Purity

≥98%

>99%

Absorption: λEx

 

 

 

λEx

 

 

 

Fluorescence: λEm

 

 

 

λEm

 

 

 

Extinction coefficient (Exc. Coe.)

30,000 ± 2,500 cm-1 M-1

 

NMR

CDCl3

Elemental Analysis

≥98%

99%

TLC

≥98%

99%

Appearance/Form

Off White Solid

Solubility

DMSO, DMF, Acetonitrile, Ethyl Acetate and Chloroform

 

  • • 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione

    • 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione

• Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995)

• Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998)

 

For Research Use Only. Not for any animal or human therapeutic

or diagnostic use

No Animal source

Regulatory Compliance

9024

Nitisinone (NTBC, Orfadin)

OSHA Hazard

No Known  OSHA Hazards

HMIS Classification

Health: 0

Flammability: 0

Physical Hazard: 0

NFPA Rating

Health: 0

Fire:  0

Reactivity: 0

TSCA Status

Not On TSCA Inventory

Transportation Information

DOT (US)

IMDG

IATA

Not dangerous goods

Not dangerous goods

Not dangerous goods